Rabbit anti Human PDCD6/ALG-2 Antibody, Polyclonal, could be used for WB, IHC, ICC, IF, Flow and so on.
Application:
WB: 0.01-2 µg/mL
IHC: 5-20 µg/mL
ICC/IF: 5-20 µg/mL
Flow: 20 µg/mL
Protein Function:
Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.