MG-132 - Moligand™, ≥98% , CAS No.133407-82-6

Name: MG-132 - Moligand™, ≥98% , CAS No.133407-82-6
SKU: M126521
Availability: InStock

CAS: 133407-82-6 Cat. No.: M126521 Formula: C₂₆H₄₁N₃O₅ Molecular Weight: 475.62 EC Number: 849-040-8

44 Citations COA

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MG-132 - Moligand™, ≥98% CAS No(133407-82-6) M126521 by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY Moligand™ ? ≥98%

Synonyms

MG132 | Z-LLL-CHO | KBio3_000059 | NCGC00161679-01 | s10322 | SMR002530629 | HMS1989B12 | n-benzyloxycarbonyl-l-leucyl-l-leucyl-l-leucinal | NCGC00161679-03 | NCGC00161679-04 | Z-Leu-leu-leucinal | KBioGR_000030 | {1-[1-(1-Formyl-3-methyl-butylcarbamoyl)-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Documents & Articles Citations of This Product Solution Calculators Reviews

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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 44 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM.
A proteasome and NF-κB inhibitor.

Specifications

Synonyms

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. These proteins processed by the proteasome are involved in inflammatory processes and cell cycle regulation

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

Pubchem Sid	528765452
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/528765452
Canonical Smiles	CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
IUPAC Name	benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
InChIKey	TZYWCYJVHRLUCT-VABKMULXSA-N
INCHI	1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
Isomeric SMILES	CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1
Molecular Weight	475.62
Reaxy-Rn	11627647
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11627647&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Peptides
        Level6 Dipeptides

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Peptides
Direct Parent	Dipeptides
Alternative Parents	Leucine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Benzyloxycarbonyls N-acyl amines Carbamate esters Secondary carboxylic acid amides Organic carbonic acids and derivatives Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Aldehydes
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Alpha-dipeptide - Leucine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Benzyloxycarbonyl - Monocyclic benzene moiety - Fatty acyl - Benzenoid - Fatty amide - N-acyl-amine - Carbamic acid ester - Secondary carboxylic acid amide - Carboxamide group - Carbonic acid derivative - Aldehyde - Organonitrogen compound - Organooxygen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
External Descriptors	carbamate ester - tripeptide - amino aldehyde
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

PSMB5 Tclin Proteasome subunit beta type-5 (1 Activities)

Discover Target: PSMB5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CTSB Tchem Cathepsin B (3822 Activities)

Discover Target: CTSB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CTSK Tchem Cathepsin K (3011 Activities)

Discover Target: CTSK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CTSS Tchem Cathepsin S (3285 Activities)

Discover Target: CTSS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CAPN2 Tchem Calpain 2 (185 Activities)

Discover Target: CAPN2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PSENEN Tchem Gamma-secretase subunit PEN-2 (38 Activities)

Discover Target: PSENEN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NFKBIA Tchem NF-kappaB inhibitor alpha (187 Activities)

Discover Target: NFKBIA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDM2 Tchem p53-binding protein Mdm-2 (4545 Activities)

Discover Target: MDM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Item
H2614610	Certificate of Analysis	Jul 22, 2026	M126521
H2614606	Certificate of Analysis	Jul 22, 2026	M126521
H2614588	Certificate of Analysis	Jul 22, 2026	M126521
H2614585	Certificate of Analysis	Jul 22, 2026	M126521
H2614575	Certificate of Analysis	Jul 22, 2026	M126521
I2517673	Certificate of Analysis	Aug 20, 2025	M126521
I2517669	Certificate of Analysis	Aug 20, 2025	M126521
I2517668	Certificate of Analysis	Aug 20, 2025	M126521
I2517666	Certificate of Analysis	Aug 20, 2025	M126521
D2613106	Certificate of Analysis	Aug 20, 2025	M126521
D2526027	Certificate of Analysis	May 10, 2025	M126521
L2420077	Certificate of Analysis	Dec 28, 2024	M126521
G2431038	Certificate of Analysis	Jul 12, 2024	M126521
A2206714	Certificate of Analysis	Oct 07, 2023	M126521
A2206709	Certificate of Analysis	Oct 07, 2023	M126521
A2206712	Certificate of Analysis	Oct 07, 2023	M126521
G1915081	Certificate of Analysis	Feb 09, 2023	M126521
A1908042	Certificate of Analysis	Sep 19, 2022	M126521
E2410029	Certificate of Analysis	Sep 08, 2022	M126521
J2215346	Certificate of Analysis	Sep 08, 2022	M126521
J2215385	Certificate of Analysis	Sep 08, 2022	M126521
J2215386	Certificate of Analysis	Sep 08, 2022	M126521
J2215387	Certificate of Analysis	Sep 08, 2022	M126521
J2215388	Certificate of Analysis	Sep 08, 2022	M126521
I2208513	Certificate of Analysis	Jun 27, 2022	M126521
I2208514	Certificate of Analysis	Jun 27, 2022	M126521
A2423030	Certificate of Analysis	Nov 25, 2021	M126521
H2409105	Certificate of Analysis	Nov 25, 2021	M126521
G2311031	Certificate of Analysis	Nov 25, 2021	M126521
G2311036	Certificate of Analysis	Nov 25, 2021	M126521

Solubility	Soluble in DMSO (25 mg/ml), 100% ethanol (25 mg/ml), chloroform:methanol solution (95:5) (10 mg/ml), water (<1 mg/ml), and DMF (~25 mg/ml).
Sensitivity	Air &Heat sensitive
Molecular Weight	475.600 g/mol
XLogP3	4.800
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	15
Exact Mass	475.305 Da
Monoisotopic Mass	475.305 Da
Topological Polar Surface Area	114.000 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	644.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

MG-132 - Moligand™, ≥98% , CAS No.133407-82-6

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

📚 Citations by Application

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