Morpholine - Distillation grade, ≥99.5% , CAS No.110-91-8

CAS: 110-91-8 Cat. No.: M109058 Molecular Weight: 87.12 Beilstein Registry Number: 102549 EC Number: 203-815-1
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GRADE & PURITY Distillation grade ? Distillation grade — purified by/for distillation with controlled volatile profile. Use where distillation behavior and low residue are important. ≥99.5%
Synonyms
C4H9NO | Drewamine | NCGC00256942-01 | J-522715 | 4-27-00-00015 (Beilstein Handbook Reference) | Diethyleneimide oxide | Tetrahydro-1,4-isoxazine | UNII-8B2ZCK305O | Tetrahydro-1, 4-isoxazine | TETRAHYDRO-2H-1, 4-OXAZINE | Tetrahydro-4H-1-4-oxazine | AI3-
Storage
Room temperature
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25ml
M109058-25ml
1
$24.90
100ml
M109058-100ml
3

$63.90

$74.90
Save $11.00 (14.69%)
500ml
M109058-500ml
1

$226.90

$336.90
Save $110.00 (32.65%)
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Why this grade

Distillation grade, ≥99.5% Distillation grade for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships FedEx DG Service Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 42 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
C4H9NO | Drewamine | NCGC00256942-01 | J-522715 | 4-27-00-00015 (Beilstein Handbook Reference) | Diethyleneimide oxide | Tetrahydro-1, 4-isoxazine | UNII-8B2ZCK305O | Tetrahydro-1, 4-isoxazine | TETRAHYDRO-2H-1, 4-OXAZINE | Tetrahydro-4H-1-4-oxazine | AI3-
Specifications & Purity
Distillation grade, ≥99.5%
Storage
Room temperature
Shipped In
FedEx DG Service
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Distillation grade
Purity
≥99.5%
Names and Identifiers
Canonical SmilesC1COCCN1
IUPAC Namemorpholine
InChIKeyYNAVUWVOSKDBBP-UHFFFAOYSA-N
INCHI1S/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H2
Isomeric SMILES C1COCCN1
WGK Germany 1
RTECS QD6475000
UN Number 2054
Packing Group I
Molecular Weight 87.12
Beilstein 102549
Reaxy-Rn 102549
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=102549&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassOxazinanes
SubclassMorpholines
Intermediate Tree Nodes Not available
Direct ParentMorpholines
Alternative Parents Oxacyclic compounds  Dialkylamines  Dialkyl ethers  Azacyclic compounds  Organopnictogen compounds  Hydrocarbon derivatives  
Molecular FrameworkAliphatic heteromonocyclic compounds
Substituents Morpholine - Oxacycle - Azacycle - Secondary amine - Ether - Secondary aliphatic amine - Dialkyl ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Amine - Aliphatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as morpholines. These are organic compounds containing a morpholine moiety, which consists of a six-member aliphatic saturated ring with the formula C4H9NO, where the oxygen and nitrogen atoms lie at positions 1 and 4, respectively.
External Descriptors morpholines - saturated organic heteromonocyclic parent
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CYP1B1 Tchem Cytochrome P450 1B1 (1148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A1 Tchem Cytochrome P450 1A1 (1169 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot NumberCertificate TypeDateItem
E2207146Certificate of AnalysisFeb 04, 2026 M109058
C2603088Certificate of AnalysisDec 05, 2024 M109058
L2412613Certificate of AnalysisDec 05, 2024 M109058
L2412616Certificate of AnalysisDec 05, 2024 M109058
L2412618Certificate of AnalysisDec 05, 2024 M109058
L2522049Certificate of AnalysisDec 05, 2024 M109058
G2318906Certificate of AnalysisJun 13, 2023 M109058
G2318915Certificate of AnalysisJun 13, 2023 M109058
G2318917Certificate of AnalysisJun 13, 2023 M109058
K2408081Certificate of AnalysisJun 13, 2023 M109058
F2229120Certificate of AnalysisJul 05, 2022 M109058
C2303200Certificate of AnalysisApr 28, 2022 M109058
E2207148Certificate of AnalysisApr 28, 2022 M109058
F23061423Certificate of AnalysisApr 28, 2022 M109058

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Chemical and Physical Properties
SolubilityIt is miscible with water and can be miscible with most organic solvents.
SensitivityHygroscopic
Refractive Index1.4548
Flash Point(°F)87.8 °F
Flash Point(°C)35℃
Boil Point(°C)128.3°C
Melt Point(°C)-4.76°C
Molecular Weight87.120 g/mol
XLogP3-0.900
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass87.0684 Da
Monoisotopic Mass87.0684 Da
Topological Polar Surface Area21.300 Ų
Heavy Atom Count6
Formal Charge0
Complexity34.500
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Distillation Grade Reagents: Definition, Quality Control and Representative Aladdin Products
OSF/ASF Dual-Channel Toolbox: Divergent Reactions of Four-Membered Ring Sulfonyl Fluorides, Condition “Knobs,” and Selection Navigation
Make “Aryl Chlorides + Low Pd Loading + Scale-Up Reproducibility” Reliable: The Initiation and Durability Logic of Pd–NHC (Palladium–N-Heterocyclic Carbene) Cross-Coupling (with Selection Navigation and Product Tables)
Why Do So Many Molecules Incorporate an “Oxadiazole Ring”? A Stability-Oriented Design Guide from Structural Effects to Application Storylines (with Product Navigation Tables 1–3)
Haloheterocycles and Cross-Coupling: A Research-Oriented Selection Framework from Substrate Identification to Bond-Forming Routes (Including Product Navigation and Tables 1–5)
β-Acyloxy Alkenyl Amides (AAAs): A New Approach to Amide Bond and Peptide Bond Construction Worth Attention
DAST-Mediated Amidation at Room Temperature: Method Features, Practical Value, and Scope of Applicability
Triphenylphosphine-Involved Carboxylic Acid Activation and Amide Bond Formation: Activation Pathways, Anhydride Competition, and Applicability Scenarios
Experimental Decision-Making for Cross-Coupling Reactions: Target Bond Type, Substrate Combination, and Catalytic System Selection
Application of Shellac, a Natural Film-Forming Resin, in Coatings: Alcohol-Soluble Fast-Drying Film Formation, Sealing and Repair, and Performance Boundaries
Citations of This Product
References
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