Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Documents & Articles Citations of This Product Solution Calculators Reviews

🧪

Why this grade

PharmPure™, USP PharmPure™,USP for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Protected from light,Room temperature Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 85 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Niacinamide, also known as 3-pyridinecarboxamide, is a water soluble vitamin. It is widely present in plants, animal food and cosmetics.

Application

Niacinamide has been used: as a component of islet maturation culture media to induce differentiation of insulin secreting cells to compare its preclinical effectiveness with that of progesterone

Specifications

Synonyms

Specifications & Purity

PharmPure™, USP

Biochemical and Physiological Mechanisms

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor Niacinamide is a primary precursor of nicotinamide adenine dinucleotide (NAD + ), which is an important coenzyme in adenosine triphosphate (ATP) production. Nicotinamide deficiency

Storage

Protected from light,Room temperature

Shipped In

Normal

Grade

PharmPure™, USP

Names and Identifiers

Pubchem Sid	504750435
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504750435
Canonical Smiles	C1=CC(=CN=C1)C(=O)N
IUPAC Name	pyridine-3-carboxamide
InChIKey	DFPAKSUCGFBDDF-UHFFFAOYSA-N
INCHI	1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
Isomeric SMILES	C1=CC(=CN=C1)C(=O)N
WGK Germany	1
RTECS	QS3675000
Molecular Weight	122.12
Beilstein	383619
Reaxy-Rn	383619
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=383619&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyridines and derivatives
    - Subclass Pyridinecarboxylic acids and derivatives
      - Level5 Pyridinecarboxamides
        Level6 Nicotinamides

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyridines and derivatives
Subclass	Pyridinecarboxylic acids and derivatives
Intermediate Tree Nodes	Pyridinecarboxamides
Direct Parent	Nicotinamides
Alternative Parents	Heteroaromatic compounds Primary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Nicotinamide - Heteroaromatic compound - Primary carboxylic acid amide - Carboxamide group - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group.
External Descriptors	a vitamin - an aliphatic amide
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

PDE5A Tclin Phosphodiesterase 5A (5113 Activities)

Discover Target: PDE5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

F2 Tclin Thrombin (11687 Activities)

Discover Target: F2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA2 Tclin Carbonic anhydrase II (17698 Activities)

Discover Target: CA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HMGCR Tclin HMG-CoA reductase (2475 Activities)

Discover Target: HMGCR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

Discover Target: NR3C1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

INSR Tclin Insulin receptor (5558 Activities)

Discover Target: INSR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PGR Tclin Progesterone receptor (8562 Activities)

Discover Target: PGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

Discover Target: ADRB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

Discover Target: CHRM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)

Discover Target: ADRB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

Discover Target: HTR1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

Discover Target: ADRA2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AR Tclin Androgen Receptor (11781 Activities)

Discover Target: AR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

Discover Target: CHRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACE Tclin Angiotensin-converting enzyme (1423 Activities)

Discover Target: ACE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD2 Tclin Dopamine D2 receptor (23596 Activities)

Discover Target: DRD2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TYR Tclin Tyrosinase (717 Activities)

Discover Target: TYR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOA Tclin Monoamine oxidase A (11911 Activities)

Discover Target: MAOA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)

Discover Target: CNR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD1 Tclin Dopamine D1 receptor (9720 Activities)

Discover Target: DRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD4 Tchem Dopamine D4 receptor (7907 Activities)

Discover Target: DRD4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

Discover Target: PTGS1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

Discover Target: SLC6A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH2 Tclin Histamine H2 receptor (5428 Activities)

Discover Target: HRH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)

Discover Target: ADRA1D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)

Discover Target: HTR1B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)

Discover Target: HTR2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)

Discover Target: HTR2C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

Discover Target: ADORA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CALCR Tclin Calcitonin receptor (2215 Activities)

Discover Target: CALCR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A4 Tclin Serotonin transporter (12625 Activities)

Discover Target: SLC6A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

Discover Target: ADRA1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

Discover Target: PTGS2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH1 Tclin Histamine H1 receptor (7573 Activities)

Discover Target: HRH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)

Discover Target: ADRA1B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRM1 Tclin Mu opioid receptor (19785 Activities)

Discover Target: OPRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD3 Tclin Dopamine D3 receptor (14368 Activities)

Discover Target: DRD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)

Discover Target: AVPR1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRD1 Tclin Delta opioid receptor (15096 Activities)

Discover Target: OPRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRK1 Tclin Kappa opioid receptor (16155 Activities)

Discover Target: OPRK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC6A3 Tclin Dopamine transporter (10535 Activities)

Discover Target: SLC6A3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 Activities)

Discover Target: HTR4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

Discover Target: PDE3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ESR2 Tclin Estrogen receptor beta (9272 Activities)

Discover Target: ESR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)

Discover Target: CYSLTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

Discover Target: Agtr2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mc4r Melanocortin receptor 4 (1205 Activities)

Discover Target: Mc4r

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ltc4s Leukotriene C4 synthase (1 Activities)

Discover Target: Ltc4s

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sigmar1 Sigma opioid receptor (160 Activities)

Discover Target: Sigmar1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Npy1r Neuropeptide Y receptor type 1 (8 Activities)

Discover Target: Npy1r

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cckar Cholecystokinin A receptor (90 Activities)

Discover Target: Cckar

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nos2 Nitric oxide synthase, inducible (3573 Activities)

Discover Target: Nos2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Faah Anandamide amidohydrolase (3907 Activities)

Discover Target: Faah

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp9 Matrix metalloproteinase 9 (38 Activities)

Discover Target: Mmp9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SIR2 NAD-dependent histone deacetylase SIR2 (218 Activities)

Discover Target: SIR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pseudomonas aeruginosa (123386 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Klebsiella pneumoniae (43867 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus aureus (210822 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Acinetobacter baumannii (41033 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Leishmania infantum (5912 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cryptococcus neoformans (21258 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Leishmania donovani (89745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trypanosoma cruzi (99888 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Toxoplasma gondii (4585 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trypanosoma brucei rhodesiense (7991 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

panE Ketopantoate reductase (28 Activities)

Discover Target: panE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GCN5 Histone acetyltransferase GCN5 (89 Activities)

Discover Target: GCN5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HST2 NAD-dependent deacetylase HST2 (97 Activities)

Discover Target: HST2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SIR2RP1 Putative silent information regulator 2 (21 Activities)

Discover Target: SIR2RP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

cobB NAD-dependent protein deacetylase (1 Activities)

Discover Target: cobB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Glra2 Glycine receptor (1745 Activities)

Discover Target: Glra2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sarm1 NAD(+) hydrolase SARM1 (23 Activities)

Discover Target: Sarm1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot Number	Certificate Type	Date	Item
E2607146	Certificate of Analysis	May 09, 2026	N434628
E2607147	Certificate of Analysis	May 09, 2026	N434628
E2607148	Certificate of Analysis	May 09, 2026	N434628
G2607148	Certificate of Analysis	May 09, 2026	N434628
G2526044	Certificate of Analysis	Aug 05, 2025	N434628
G2526056	Certificate of Analysis	Aug 04, 2025	N434628
G2526038	Certificate of Analysis	Jul 30, 2025	N434628
L2508147	Certificate of Analysis	Jul 30, 2025	N434628
C2517333	Certificate of Analysis	Feb 26, 2025	N434628
C2517334	Certificate of Analysis	Feb 26, 2025	N434628
J2417606	Certificate of Analysis	Sep 27, 2024	N434628
J2417615	Certificate of Analysis	Sep 27, 2024	N434628
J2417616	Certificate of Analysis	Sep 27, 2024	N434628
I2311546	Certificate of Analysis	Aug 30, 2023	N434628
I2311547	Certificate of Analysis	Aug 30, 2023	N434628

Chemical and Physical Properties

Sensitivity	Light sensitive
Flash Point(°F)	302 °F
Flash Point(°C)	150 °C
Melt Point(°C)	128-131°C
Molecular Weight	122.120 g/mol
XLogP3	-0.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	122.048 Da
Monoisotopic Mass	122.048 Da
Topological Polar Surface Area	56.000 Å²
Heavy Atom Count	9
Formal Charge	0
Complexity	114.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Documents & Articles

From Spec to Bench: Understanding and Using USP Grade Reagents

Categories: Reagent Specifications, Grading and Purity

Tags:

USP grade

NADH vs NADPH: Homologous coenzymes with distinct functional specialization

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

NADH NADPH Coenzymes

Small-Molecule Inhibitors: A Practical Guide for Research Selection — A Minimal Evidence Chain and Scenario-Based Validation Framework (Including a Selection Matrix, Case Cards, and Product Tables 1–4)

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Small-Molecule Inhibitors

Niacin (Vitamin B3): Structural Features, Metabolic Roles, and Application Landscape

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Pharmaceutical Intermediates Niacin Vitamin B3 Nicotinamide NADP+ Niacin equivalents Nutritional fortification Feed additive

From Piperidine to Pyridine: The “Most Common N-Heterocycle” Shift in FDA Small-Molecule New Drugs (2013–2023) and a Selection Guide (Tables 1–4)

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

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N-Heterocycle

Vitamins, Coenzymes, and Enzymes: A Metabolic Synergy Network and Its Disease Associations

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

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REDOX Vitamins Coenzymes Enzymes holoenzymes cofactors group transfer one-carbon metabolism metabolic flux disease associations

NAD (Nicotinamide Adenine Dinucleotide): From a Metabolic Coenzyme to Homeostatic Regulation and Application Targets

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

NAD NAD⁺/NADH NADP⁺/NADPH Salvage synthesis Preiss-Handler Denovo synthesis NAD-consuming enzymes Homeostasis Aging

Pyridine Research Selection Roadmap: Structural Features, Reaction Logic, and a Classification Navigator for Reagents/Building Blocks/Reference Standards (Tables 1–6)

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Pyridine ring Pyridine

Functional System Overview of Cellular Metabolic Enzymes in Energy Metabolism, Redox, and Signal Transduction

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

REDOX NADPH ROS Signal Transduction metabolic enzymes energy metabolism NADH/NAD metabolite signaling flux analysis

Roles of One-Carbon Metabolism Enzymes in Oxidative Stress and Epigenetic Regulation in Cardiovascular Diseases

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Cardiovascular diseases one-carbon metabolism Oxidative Stress homocysteine transsulfuration pathway Nrf2 Folate Cycle Methionine Cycle Epigenetic Regulation S-Adenosylmethionine

Acetyl-Group Metabolic Enzyme Network and In Vitro Enzymology Analysis

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Epigenetic Regulation Acetyl-Group Metabolism Acetyl-Coa Acetyltransferases Deacetylases Pathway Analysis In Vitro Enzymology Central Carbon Metabolism

Noncanonical Functions of Epigenetic Enzymes and Regulation of Mitochondrial Metabolism

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

epigenetic enzymes noncanonical functions mitochondrial metabolism mtDNA mitochondrial protein acetylation DNMT1 MOF LSD1

Three-Dimensional Chromatin Architecture Remodeling and Mechanisms of Physiological Aging

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

three-dimensional chromatin physiological aging A/B compartments topologically associating domains chromatin loops lamina-associated domains heterochromatin

Understanding Ceramides from the Perspective of the Stratum Corneum Lipid Barrier: Moisturizing and Barrier-Repair Mechanisms, Ingredient Selection, and Formulation Research Considerations

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Nicotinamide Ceramides

Establishment and Evaluation Methods of Diabetic Animal Models

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Tags:

diabetic animal modeling STZ-induced model alloxan model high-fat diet model HFD+STZ model NOD mice db/db mice ZDF rats

Mechanistic Analysis of Topical Glutathione in Skincare: Cellular Redox Regulation, Skin Delivery Challenges, and SLN-Based Delivery Strategies

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

glutathione Cellular redox

Mechanism of Kojic Acid in Reducing Hyperpigmentation: From Tyrosinase Inhibition to Melanin Production Regulation

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Natural Pigment tyrosinase Melanin

Research on Cell Cycle and DNA Damage Response Mechanisms

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Cell Cycle DNA damage response G1/S checkpoint G2/M checkpoint ATM ATR Chk1 Chk2 CDK genome stability

If the DNA Sequence Remains Unchanged, Why Does Gene Expression Change? Core Mechanisms and Research Methods of Epigenetic Regulation

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

DNA Epigenetics gene expression

Analysis of Hydrolyzed Pearl as a Cosmetic Raw Material: Preparation Process, Active Components, and Skincare Formulation Applications

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

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Hydrolyzed Pearl

The Dual-Targeted Skin-Brightening Mechanism of 4-MSK: Inhibiting Melanin Production and Reducing Epidermal Pigment Retention

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Potassium 4-Methoxysalicylate 4-MSK INCI

Antioxidant Mechanisms, Stability, and Delivery Strategies of Resveratrol in Skincare Research

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Resveratrol

Probiotics, Prebiotics, and Postbiotics in Skin Care: Conceptual Distinctions, Mechanisms of Action, and Their Applications in the Care of Dry, Itchy, and Rough Skin

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skin care Probiotics

How Do Collagen Peptides Act on the Skin? From Surface Hydration and Percutaneous Delivery to Fibroblasts and Collagen Homeostasis

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skin care collagen peptide

Phenylethyl Resorcinol (377): Structural Characteristics, Melanogenesis-Regulating Mechanisms, and Related Applications in Formulation Research

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cosmetics Phenylethyl Resorcinol

Potential Mechanisms of Succinic Acid in Acne Care: From Dicarboxylic Acid–Base Equilibria to Metabolic Antagonism Among Skin Microorganisms

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Succinic Acid Acne

Anti-Photoaging Potential of Artemia Extract: UV-Induced Damage Cascades, HSP70-Related Stress Protection, and GP4G Metabolic Insights

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Artemia Extract UV-Induced Damage

Regulatory Mechanisms, Research Methods, and Modification-Omics Analysis of Protein Post-Translational Modifications

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Glycosylation methylation SUMOylation Protein Post-Translational Modifications Ubiquitination Phosphorylation Acetylation Lactylation Modification Proteomics

The Sebum-Regulating Potential of Zinc PCA and Its Relationship with Stratum Corneum Hydration

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Sebum regulation Zinc PCA Sebaceous gland

Mechanism of Action of Tranexamic Acid in Pigmentation Care: From the Plasmin System to Regulation of Inflammation-Driven Pro-Melanogenic Signaling

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Tranexamic Acid TXA

How Arbutin Regulates Melanin Production: α/β Anomeric Configuration and Tyrosinase Action

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Melanin Arbutin

Mechanisms of Action, Formulation Screening, and Safety Evaluation of Solubilizers, Hydrotropes, and Cosolvents in Drug-Delivery Systems

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Surfactants solubilizers hydrotropes cosolvents poorly soluble drugs micellar solubilization hydrotropy mixed solvents dilution-induced precipitation drug-delivery formulations

Regulatory Mechanisms of Aging-Related Nutrient Sensing, Inflammation, and Homeostatic Signaling Pathways

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Autophagy Aging mTOR AMPK senescence-associated secretory phenotype IIS IGF-1 Sirtuins

Mechanistic Basis of Acetyl Hexapeptide-8 in the Management of Expression Lines: SNARE Complex Interference, Constraints on Percutaneous Delivery, and Combination Strategies

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Retinol Acetyl Hexapeptide-8 Argireline SNAP-25 SNARE complex expression lines transdermal delivery anti-wrinkle combinations

Niacinamide Brightening Mechanisms and Formulation Design: Melanosome Transfer, pH Regulation, and Combination Strategies

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Niacinamide

Molecular Mechanisms by Which Natural Products Regulate Adipose Browning

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Natural products AMPK adipose browning white adipose tissue UCP1 PGC-1α Hyperforin non-shivering thermogenesis

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Cell proliferation3

Cell viability4

Cytotoxicity screening5

Drug / compound screening16

Extraction & workup solvent25

Organic synthesis — reaction medium36

Controlled-release & nanoparticle carrier8

Electrochemistry & battery electrolyte6

Crystallization & recrystallization11

Chromatography (HPLC / GC / TLC)18

Other applications28

Spectroscopy sample preparation7

Polymer synthesis & polymerization3

Topical & ophthalmic formulation5

Film coating1

IC50 determination1

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Niacinamide - PharmPure™, USP , CAS No.98-92-0

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

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