Mouse anti Rat/Mouse Transferrin Receptor/CD71 Antibody, Monoclonal (OX-26), could be used for Flow, IHC, Targeted drug delivery to the brain and so on.
Application
Flow: Use at an assay dependent concentration.
IHC: Use at an assay dependent concentration.
Targeted drug delivery to the brain: Use at an assay dependent concentration.
Protein Function
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.