Trifluoromethanesulfonic acid(TFMSA) - ≥99.5% , CAS No.1493-13-6

CAS: 1493-13-6 Cat. No.: T398955 Molecular Weight: 150.08 Beilstein Registry Number: 3693487 EC Number: 216-087-5 PubChem CID: 62406
AVAILABLE TO ORDER
GRADE & PURITY ≥99.5%
Synonyms
Trifluoromethane sulfonic acid | Triflic acid | Trifluoromethylsulfonic acid | HOTf | tfmsa | TFMS | TfOH | Trifluoromethanesulphonic acid | Perfluoromethanesulfonic acid | METHANESULFONIC ACID, TRIFLUORO- | 1493-13-6
Storage
Room temperature,Argon charged,Desiccated
Shipped In
Normal
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
10g
T398955-10g
2
$39.90
25g
T398955-25g
3
$79.90
100g
T398955-100g
3
$229.90
250g
T398955-250g
2

$370.90

$432.90
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Why this grade

≥99.5% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature,Argon charged,Desiccated Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 223 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
Trifluoromethane sulfonic acid | Triflic acid | Trifluoromethylsulfonic acid | HOTf | tfmsa | TFMS | TfOH | Trifluoromethanesulphonic acid | Perfluoromethanesulfonic acid | METHANESULFONIC ACID, TRIFLUORO- | 1493-13-6
Specifications & Purity
≥99.5%
Storage
Room temperature, Argon charged, Desiccated
Shipped In
Normal
Purity
≥99.5%
Names and Identifiers
Pubchem Sid504753841
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504753841
Canonical SmilesC(F)(F)(F)S(=O)(=O)O
IUPAC Nametrifluoromethanesulfonic acid
InChIKeyITMCEJHCFYSIIV-UHFFFAOYSA-N
INCHI1S/CHF3O3S/c2-1(3,4)8(5,6)7/h(H,5,6,7)
Isomeric SMILES C(F)(F)(F)S(=O)(=O)O
WGK Germany 2
PubChem CID 62406
UN Number 3265
Packing Group II
Molecular Weight 150.08
Beilstein 3693487
Reaxy-Rn 1812100

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassOrganic sulfonic acids and derivatives
SubclassOrganosulfonic acids and derivatives
Intermediate Tree Nodes Alkanesulfonic acids and derivatives - Alkanesulfonic acids
Direct ParentTrifluoromethanesulfonates
Alternative Parents Sulfonyls  Organosulfonic acids  Methanesulfonates  Trihalomethanes  Organofluorides  Organic oxides  Hydrocarbon derivatives  Alkyl fluorides  
Molecular FrameworkAliphatic acyclic compounds
Substituents Trifluoromethanesulfonate - Sulfonyl - Organosulfonic acid - Methanesulfonate - Trihalomethane - Organic oxygen compound - Organic oxide - Halomethane - Hydrocarbon derivative - Organosulfur compound - Organofluoride - Organohalogen compound - Alkyl halide - Alkyl fluoride - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as trifluoromethanesulfonates. These are alkanesulfonic acids, that contain a sulfonate group that is substituted with a trifluoromethyl group.
External Descriptors organofluorine compound - one-carbon compound - organosulfonic acid - sulfur oxoacid derivative
3D Structure
Interactive Chemical Structure Model





Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
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36 results found

Lot NumberCertificate TypeDateItem
F2624157Certificate of AnalysisJun 29, 2026 T398955
E2629079Certificate of AnalysisJun 25, 2026 T398955
L2402007Certificate of AnalysisJun 11, 2026 T398955
E2629078Certificate of AnalysisJun 10, 2026 T398955
E2629080Certificate of AnalysisJun 10, 2026 T398955
E2629081Certificate of AnalysisJun 09, 2026 T398955
H2321022Certificate of AnalysisFeb 05, 2026 T398955
A2616130Certificate of AnalysisJan 20, 2026 T398955
A2616129Certificate of AnalysisJan 20, 2026 T398955
A2616128Certificate of AnalysisJan 20, 2026 T398955
C2520267Certificate of AnalysisJan 19, 2026 T398955
C2520308Certificate of AnalysisJan 19, 2026 T398955
H2321060Certificate of AnalysisDec 12, 2025 T398955
H2321021Certificate of AnalysisDec 12, 2025 T398955
C2525081Certificate of AnalysisApr 11, 2025 T398955
A2607147Certificate of AnalysisMar 28, 2025 T398955
C2520268Certificate of AnalysisMar 28, 2025 T398955
L2402008Certificate of AnalysisDec 13, 2024 T398955
L2403045Certificate of AnalysisDec 11, 2024 T398955
L2403075Certificate of AnalysisDec 10, 2024 T398955
J2408549Certificate of AnalysisSep 21, 2024 T398955
J2408788Certificate of AnalysisSep 21, 2024 T398955
J2408789Certificate of AnalysisSep 21, 2024 T398955
J2408790Certificate of AnalysisSep 21, 2024 T398955
F2406036Certificate of AnalysisJun 20, 2024 T398955
F23021063Certificate of AnalysisMar 21, 2024 T398955
F23021062Certificate of AnalysisMar 21, 2024 T398955
F23021059Certificate of AnalysisMar 21, 2024 T398955
F23021058Certificate of AnalysisMar 21, 2024 T398955
F23021055Certificate of AnalysisMar 21, 2024 T398955
F23021056Certificate of AnalysisMay 12, 2023 T398955
C2310622Certificate of AnalysisMar 20, 2023 T398955
H2209762Certificate of AnalysisJun 18, 2022 T398955
H2209763Certificate of AnalysisJun 18, 2022 T398955
H2209764Certificate of AnalysisJun 18, 2022 T398955
D2319409Certificate of AnalysisJun 18, 2022 T398955

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Chemical and Physical Properties
SolubilityDissolve with water
SensitivityHygroscopic;Air sensitive
Refractive Index1.326-1.33
Flash Point(°F)332.1 °F
Flash Point(°C)> 166.7 °C
Boil Point(°C)162°C
Melt Point(°C)-40°C
Molecular Weight150.080 g/mol
XLogP30.300
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Exact Mass149.96 Da
Monoisotopic Mass149.96 Da
Topological Polar Surface Area62.800 Ų
Heavy Atom Count8
Formal Charge0
Complexity158.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Friedel–Crafts Acylation
What is Friedel Craft reaction with example?
What are the advantages of Friedel Crafts acylation?
Is Friedel-Crafts alkylation reversible?
How is a Lewis acid used in Friedel Crafts acylation?
What is alkylation of benzene?
Why does nitrobenzene not undergo the Friedel-Crafts acylation reaction?
What are the limitations of Foucault alkylation reaction?
What are the limitations of the Foucault acylation reaction?
Asymmetric Organocatalysts
MacMillan Imidazolidinone Organocatalysts
Boc resin lysis protocol
3-Chloroperoxybenzoic acid, m-CPBA
A Complete Guide to Ion-Pair Reversed-Phase Chromatography (IPC / IP-RP): Mechanisms, Four Tuning Knobs, Troubleshooting, and Ion-Pair Reagent Families (Tables 1–4)
How Organic Acids “Stabilize a System”: Selection Logic via the pH Window, Salt Forms, and Metal-Ion Management (with a navigation guide to Tables A–E)
From the Logic of Deprotection to Protecting Group Choice: Differences Among Bn, PMB, and Dmb in Experimental Design
Reassessing Trimethylaluminum: Method Design and Experimental Value of One-Pot Peptide Elongation from Unprotected Amino Acids
Selective Deprotection and Sulfonyl Group Migration of N-Aryl Sulfonamides Mediated by TfOH (Trifluoromethanesulfonic Acid): Reaction Patterns and Synthetic Implications
Citations of This Product
References
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47. Lingling Ma, Lv Li, Minghao Yuan, Lei Bai, Anran Zhang, Xiaoming Yan, Gaohong He, Fengxiang Zhang.  (2022)  Hydrophilic–Hydrophobic Bulky Units Modified Anion Exchange Membranes for Fuel Cell Application.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.1c07886]
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49. Xiaoyu Yao, Xuan Meng, Jie Yin, Tao Yin, Tianyi Luo, Naiwang Liu, Li Shi.  (2022)  Efficient removal of trace olefins in aromatics by novel acetamide-based acidic deep eutectic solvents.  FUEL,      [PMID:] [10.1016/j.fuel.2021.123103]
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66. Huinan Guo, Weiqin Li, Kai Chen, Mengyuan Yue, Yike Huang, Yafei Liu, Huaxu Shao, Chengcheng Chen, Caiyun Wang, Yijing Wang.  (2021)  Strategic Structure Tuning of Yolk-Shell Microcages for Efficient Nitrogen Fixation.  ChemSusChem,  14  (12): (2521-2528).  [PMID:33830646] [10.1002/cssc.202100502]
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78. Xiaoxue Hou, Lijun Yang, Jinjian Liu, Yumin Zhang, Liping Chu, Chunyan Ren, Fan Huang, Jianfeng Liu.  (2020)  Silver-decorated, light-activatable polymeric antimicrobials for combined chemo-photodynamic therapy of drug-resistant bacterial infection.  Biomaterials Science,  (22): (6350-6361).  [PMID:33025982] [10.1039/D0BM01084G]
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86. Jinyi Chen, Meichen Li, Mantian Li, Xiaocheng Lin, Ting Qiu.  (2020)  Self-Solidifying Quaternary Phosphonium-Containing Ionic Liquids as Efficient and Reusable Catalysts for Biodiesel Production.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.9b07432]
87. Wenhuan Wang, Lin Sang, Qingbo Guan, Yiping Zhao, Zhiyong Wei, Yang Li.  (2020)  X-ray visible microspheres derived from highly branched biodegradable poly(lactic acid) terminated by triiodobenzoic acid: Preparation and degradation behavior.  POLYMER DEGRADATION AND STABILITY,      [PMID:] [10.1016/j.polymdegradstab.2020.109149]
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104. Zhong-Qiu Liu, Xian-Yong Wei, Fang-Jing Liu, Guang-Hui Liu, Zhi-Min Zong.  (2018)  Catalytic hydroconversion of Yiwu lignite over solid superacid and solid superbase.  FUEL,      [PMID:] [10.1016/j.fuel.2018.10.051]
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106. Wei Hui, Yan Zhou, Yan Dong, Zhi-Jun Cao, Fei-Qiang He, Min-Zhong Cai, Duan-Jian Tao.  (2018)  Efficient hydrolysis of hemicellulose to furfural by novel superacid SO4H-functionalized ionic liquids.  Green Energy & Environment,      [PMID:] [10.1016/j.gee.2018.06.002]
107. Zheng Yang, Xian-Yong Wei, Min Zhang, Dao-Guang Teng, Ya-Nan Wang, Zhong-Qiu Liu, Zhi-Min Zong.  (2018)  Enhanced hydrocracking Car-Calk bridged bonds in the extraction residue from Piliqing subbituminous coal over a recyclable and active magnetic solid superacid.  FUEL PROCESSING TECHNOLOGY,      [PMID:] [10.1016/j.fuproc.2018.03.034]
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110. Zichen Xu, Guoying Zhao, Latif Ullah, Meng Wang, Aoyun Wang, Yanqiang Zhang, Suojiang Zhang.  (2018)  Acidic ionic liquid based UiO-67 type MOFs: a stable and efficient heterogeneous catalyst for esterification.  RSC Advances,  (18): (10009-10016).  [PMID:35540816] [10.1039/C8RA01119B]
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120. Yingying Ren, Zhiyong Wei, Tong Wu, Yufei Bian, Xuefei Leng, Cheng Zhou, Yang Li.  (2016)  Synthesis of highly branched poly(δ-valerolactone)s: a comparative study between comb and linear analogues.  RSC Advances,  (51): (45791-45801).  [PMID:] [10.1039/C6RA09289F]
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124. Mei-Xia Zhao, Xian-Yong Wei, Meng Qu, Zhan-Ku Li, Jing Liu, Jiao Kong, Dong-Dong Zhang, Hong-Lei Yan, Zhi-Min Zong.  (2015)  A highly active solid acid for specifically catalyzing di(1-naphthyl)methane hydrocracking in cyclohexane.  FUEL PROCESSING TECHNOLOGY,      [PMID:] [10.1016/j.fuproc.2015.10.030]
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198. Jialin Zhao, Jian Gao, Jiayao Yang, Yijia Lei, Yanchao Zhang, Yiman Gu, Yan Wang, Wenyu Gao, Jin-bo Zhao, Zhe Wang.  (2024)  Hydrophobic Thiophene Unit Modification for the Construction of Novel Anion Exchange Membranes for High-Speed Transport of Ion Channels.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.4c03910]
199. Wang Wei, Guo Ruixiang, Zheng Aodi, Jin Xiaorui, Jia Xiongjie, Ren Zhiwei, Han Yangkai, Zhang Lifeng, Zhai Yeming, Liu Xiaofen, Jiang Haoran, Zhao Yun, Zhou Kai-Ge, Wu Meiling, Jiang Zhongyi.  (2025)  Promoting in-situ stability of hydroxide exchange membranes by thermally conductive network for durable water electrolysis.  Nature Communications,  16  (1): (1-12).  [PMID:39843436] [10.1038/s41467-025-56262-6]
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218. Gege Li, Weiran Chen, Weiwei Luan, Jibin Miao, Bin Wu, Guangzu Wang, Ru Xia, Jiasheng Qian, Qianqian Ge.  (2026)  A π-conjugated anion exchange membrane with interconnected ions-transportation channels for AEMWEs.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2026.125283]
219. Xuewen Tang, Mehdihasan Shekh, Mingliang Li, Kaijin Guo, Mengfei Wang, Chengtian Zhu, Guangming Zhu.  (2026)  Highly Conductive and Mechanically Robust Isatin-Derived Anion Exchange Membranes for Water Electrolysis.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.5c04615]
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223. Zhaoguo Zhang, Dan Mei, Noor Ul Afsar, Yanan Chen, Jin Tang, Ke Liu, Jawad Ali, Dong Wang.  (2026)  Eco-efficient design of vinyl carbazole derived anion exchange membranes with controlled d-spacing for high-performance acid recovery and metal ion exclusion.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2026.138124]
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