Mouse anti Human/Monkey CD154/CD40L Antibody, Monoclonal (5C8), could be used for in vitro blocking of CD40/CD40L signaling, in vivo blocking of CD40/CD40L signaling, IP, Flow and so on.
Application:
in vitro blocking of CD40/CD40L signaling: Use at an assay dependent concentration.
in vivo blocking of CD40/CD40L signaling: Use at an assay dependent concentration.
IP: Use at an assay dependent concentration.
Flow: Use at an assay dependent concentration.
Protein Function
Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.