L-Ascorbic acid - UltraBio™, Ultra pure, ≥99.5%(RT) , CAS No.50-81-7

CAS: 50-81-7 Cat. No.: L432790 Formula: C₆H₈O₆ Molecular Weight: 176.12 Beilstein Registry Number: 84272 EC Number: 200-066-2

GRADE & PURITY UltraBio™, Ultra pure, ≥99.5%(RT)

Synonyms

Ascorbicap | C-Long | Ferrous ascorbate | phosphorus oxichloride | Ceglion | Cenetone | Cetemican | hexamethyl-disiloxane | Ascorb | Cemagyl | Cipca | Planavit C | Secorbate | Vitacee | Ascorbicab | Scorbacid | Cecon | C-Span | Duoscorb | pentakis(chloran

Storage

Protected from light,Room temperature,Desiccated

Shipped In

Normal

Overview

Gene Information

human ... SLC23A2(9962)

General Description

L-Ascorbic acid, also known as vitamin C, is a water-soluble vitamin. It is naturally present in a variety of foods such as citrus fruits and vegetables. It is present only in minimal amount in milk.

Application

L-Ascorbic acid has been used as an antioxidant supplement in incubation solution for dissected and sliced brain sections. It has also been used as a supplement in phosphate-buffered saline (PBS) wash buffer during oxidative GFP chromophore formation.

Other Notes

Denaturation of proteins; Dimeric association of E. coli RNA polymerase α subunits, studied by cleavage of single cysteine α subunits conjugated to Fe-BABE.

Specifications

Synonyms

Ascorbicap | C-Long | Ferrous ascorbate | phosphorus oxichloride | Ceglion | Cenetone | Cetemican | hexamethyl-disiloxane | Ascorb | Cemagyl | Cipca | Planavit C | Secorbate | Vitacee | Ascorbicab | Scorbacid | Cecon | C-Span | Duoscorb | pentakis(chloran

Specifications & Purity

UltraBio™, Ultra pure, ≥99.5%(RT)

Biochemical and Physiological Mechanisms

L-ascorbic acid mainly has antioxidant properties. It protects plants from oxidative stress and mammals from diseases related to oxidative stress. L-ascorbic acid mainly plays a protective role against hydroxyl radicals, superoxide, and singlet oxygen. In

Storage

Protected from light,Room temperature,Desiccated

Shipped In

Normal

Grade

Ultra pure, UltraBio™

Action Type

INHIBITOR

Purity

≥99.5%(RT)

Names and Identifiers

Pubchem Sid

508810603

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/508810603

Canonical Smiles

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

IUPAC Name

(2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one

InChIKey

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

INCHI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

Isomeric SMILES

C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O

WGK Germany

1

RTECS

CI7650000

Alternate CAS

53262-66-1,6730-29-6,50-81-7,134-03-2 (monosodium salt)

MeSH Entry Terms

Acid, Ascorbic;Acid, L-Ascorbic;Ascorbate, Ferrous;Ascorbate, Magnesium;Ascorbate, Sodium;Ascorbic Acid;Ascorbic Acid, Monosodium Salt;di-L-Ascorbate, Magnesium;Ferrous Ascorbate;Hybrin;L Ascorbic Acid;L-Ascorbic Acid;Magnesium Ascorbate;Magnesium Ascorbi

Molecular Weight

176.12

Beilstein

84272

Reaxy-Rn

84272

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=84272&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Dihydrofurans
      • Subclass Furanones

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Dihydrofurans
• Subclass: Furanones
• Intermediate Tree Nodes: Not available
• Direct Parent: Butenolides
• Alternative Parents: Vinylogous acids Enoate esters Secondary alcohols Lactones Enediols 1,2-diols Oxacyclic compounds Monocarboxylic acids and derivatives Primary alcohols Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: 2-furanone - Vinylogous acid - Alpha,beta-unsaturated carboxylic ester - Enoate ester - 1,2-diol - Carboxylic acid ester - Enediol - Secondary alcohol - Lactone - Carboxylic acid derivative - Oxacycle - Monocarboxylic acid or derivatives - Alcohol - Hydrocarbon derivative - Organic oxygen compound - Carbonyl group - Organic oxide - Primary alcohol - Organooxygen compound - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as butenolides. These are dihydrofurans with a carbonyl group at the C2 carbon atom.
• External Descriptors: Water-soluble vitamins

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ADRA2B Tclin Alpha-2B adrenergic receptor (0 Activities)

Discover Target: ADRA2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Lymphoblastoid cell (5959 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 (14536 Activities)

Discover Target: L3MBTL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

lef Anthrax lethal factor (7585 Activities)

Discover Target: lef

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TGR Thioredoxin glutathione reductase (28579 Activities)

Discover Target: TGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: H2O: 1M at20°C, clear, colorless
• Sensitivity: Light sensitive
• Specific Rotation[α]: 21 ° (C=10, H2O)
• Melt Point(°C): 190-192°C
• Molecular Weight: 176.120 g/mol
• XLogP3: -1.600
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 176.032 Da
• Monoisotopic Mass: 176.032 Da
• Topological Polar Surface Area: 107.000 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 232.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1