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JNJ-42165279 - 98%, high purity , CAS No.1346528-50-4, Inhibitor of Fatty acid amide hydrolase Specifications & Purity: 98%
Basic Description Synonyms JNJ-42165279|1346528-50-4|N-(4-Chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide|JNJ42165279|AH2E5UQ11Y|N-(4-chloropyridin-3-yl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine-1-carboxamide|1-Piperazinec Specifications & Purity 98% Storage Temp Protected from light,Store at -20°C Shipped In Dry ice Action Type INHIBITOR Mechanism of action Inhibitor of Fatty acid amide hydrolase Product Description Information
JNJ-42165279 JNJ-42165279 (JNJ-5279) is an inhibitor of fatty acid amide hydrolase (FAAH) that inhibits recombinant human and rat FAAH with IC50 of 70 nM and 313 nM, respectively.
Targets
recombinant human FAAH (Cell-free assay); recombinant rat FAAH (Cell-free assay) 70 nM; 313 nM
Product Properties ALogP 4.009 HBD Count 1 Rotatable Bond 3
Names and Identifiers IUPAC Name N-(4-chloropyridin-3-yl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine-1-carboxamide INCHI InChI=1S/C18H17ClF2N4O3/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15/h1-4,9-10H,5-8,11H2,(H,23,26) InChi Key YWGYNGCRVZLMCS-UHFFFAOYSA-N Canonical SMILES C1CN(CCN1CC2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4=C(C=CN=C4)Cl Isomeric SMILES C1CN(CCN1CC2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4=C(C=CN=C4)Cl Alternate CAS 1346528-50-4 PubChem CID 54576693 MeSH Entry Terms 1-piperazinecarboxamide, N-(4-chloro-3-pyridinyl)-4-((2,2-difluoro-1,3-benzodioxol-5-yl)methyl)-;JNJ-42165279;N-(4-chloro-3-pyridinyl)-4-((2,2-difluoro-1,3-benzodioxol-5-yl)methyl)-1-piperazinecarboxamide Molecular Weight 410.8
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 82 mg/mL (199.61 mM); Ethanol: 82 mg/mL (199.61 mM); Water: Insoluble; Sensitivity light sensitive DMSO(mg / mL) Max Solubility 82 DMSO(mM) Max Solubility 199.610516066212 Water(mg / mL) Max Solubility ＜1
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
H361: Suspected of damaging fertility or the unborn child
H361f: Suspected of damaging fertility
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
References 1. Keith JM, Jones WM, Tichenor M, Liu J, Seierstad M, Palmer JA, Webb M, Karbarz M, Scott BP, Wilson SJ et al. . (2015) Preclinical Characterization of the FAAH Inhibitor JNJ-42165279.. ACS Med Chem Lett, 6 (12): (1204-8). [PMID:26713105 ]
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