GPR18, GPR55 and GPR119

GPR18: It is a receptor for endogenous lipid neurotransmitters and has been found to be involved in the regulation of intraocular pressure. Although there are multiple reports to indicate that GPR18 can be activated in vitro by N-arachidonoylglycine, there is a lack of evidence for activation by these lipid messengers in vivo. GPR55: It has been found to be involved in the regulation of various physiological processes such as inflammation, pain, and cancer. GPR55 is activated by lysophosphatidylinositol and 2-arachidonoylglycerolphosphoinositol. GPR119: It is a receptor for endogenous lipid neurotransmitters and has been found to be involved in the regulation of glucose homeostasis and insulin secretion. GPR119 is activated by N-oleoylethanolamide and N-palmitoylethanolamine.