Platelet-activating factor receptor

The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor that binds to platelet-activating factor (PAF). It is encoded by the PTAFR gene in humans and is present in the plasma and nuclear membranes of most cells of the vascular and innate immune system. PAF-R is involved in a variety of pathways that are associated with inflammation, oncogenic transformation, tumor growth, angiogenesis, and metastasis .