Isocitrate dehydrogenases (IDH) are a group of enzymes that catalyze the oxidative decarboxylation of isocitrate to produce alpha-ketoglutarate and carbon dioxide. The reaction occurs in two steps: first, isocitrate is oxidized to oxalosuccinate, and then oxalosuccinate is decarboxylated to form alpha-ketoglutarate. IDHs are classified into three isoforms: IDH1, IDH2, and IDH3. IDH1 and IDH2 are NADP±dependent enzymes that function in the cytoplasm and mitochondria, respectively. IDH3 is an NAD±dependent enzyme that functions in the mitochondria.
1.1.1.42 Isocitrate dehydrogenases
- Olutasidenib (FT-2102), Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor
Cas#:1887014-12-1
Starting at $206.90
- LY3410738, Inhibitor of isocitrate dehydrogenase (NADP(+)) 1;Inhibitor of isocitrate dehydrogenase (NADP(+)) 2
Cas#:2230263-60-0
Starting at $920.90
- safusidenib, Inhibitor of isocitrate dehydrogenase (NADP(+)) 1
Cas#:1898206-17-1
Starting at $700.90