Cross-Coupling

Cross-coupling is a chemical reaction between two or more molecules that results in the formation of a new chemical bond. It is a widely used method in organic synthesis for the preparation of complex molecules with high precision and efficiency. Cross-coupling reactions are particularly useful for the construction of carbon-carbon bonds, which are important for the synthesis of a wide range of compounds, including pharmaceuticals, agrochemicals, and materials. There are several types of cross-coupling reactions, including Suzuki-Miyaura cross-coupling, Heck reaction, Negishi reaction, and Stille reaction, among others. These reactions are typically performed using a transition metal catalyst, such as palladium, nickel, or iron, which plays a crucial role in facilitating the reaction and promoting the formation of the desired product. Cross-coupling reactions have become an essential tool in modern organic synthesis, providing a convenient and versatile method for the preparation of complex organic compounds. They are widely used in both academic and industrial settings, and have played a significant role in advancing the fields of medicinal chemistry, materials science, and more.