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Pyruvate kinases (PKs) are a family of enzymes that catalyze the transfer of a phosphate group from ATP to pyruvate, producing phosphoenolpyruvate (PEP) and ADP. This reaction is the final step in the glycolytic pathway, which is a process that converts glucose into pyruvate and generates ATP. PKs are expressed in a variety of tissues, including the liver, muscle, and brain.
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