1.4.3.13 Lysyl oxidases

Lysyl oxidases (LOXs) are a family of copper-dependent enzymes that catalyze the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, leading to the formation of aldehydes and reactive carbonyl groups. LOXs are involved in the cross-linking of collagen and elastin fibers, which is essential for the structural integrity of connective tissues such as skin, bone, and cartilage.