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Chemical Biology

Chemical biology tools to interrogate biological systems with small molecules. Find probes, labels, and bioactive compounds (where available) to support target engagement studies, pathway mapping, and assay development.

Browse by type, application, or key specifications such as purity, grade, packaging, and handling requirements.

25,547 products
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👆 Click Chemistry
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Biotinylation reagents

111

Explore biotinylation reagents for labeling, pull-down workflows, target capture, and assay development. Compare reactive biotin tools suited to protein, peptide, and other biomolecule modification.

Explore Biotinylation reagents →

Chromogenic and chemiluminescent substrates

89

Browse chromogenic and chemiluminescent substrates for enzyme assays, signal generation, and detection workflows. Use these reagents to support sensitive readouts in bioanalytical applications.

Explore Chromogenic and chemiluminescent substrates →

Fluorescent probes

3,330

Explore fluorescent probes for imaging, labeling, tracking, and assay readouts across biological workflows. Compare probes that support detection in cells, biomolecules, and analytical systems.

Explore Fluorescent probes →

Protein Degrader Building Blocks

20,634

Source protein degrader building blocks for PROTAC and targeted degradation chemistry. This page helps you identify linkable components for degrader design and optimization.

Explore Protein Degrader Building Blocks →

PEG Linkers

19

Browse PEG linkers for conjugation, linker design, and biomolecule modification. Use these reagents to tune spacing, solubility, and architecture in chemical biology workflows.

Explore PEG Linkers →

Chemical Biology Tools

143

Find chemical biology tools for labeling, modulation, target interrogation, and biomolecule-focused experiments. This category helps you source practical reagents for mechanism and assay workflows.

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Crosslinkers

466

Browse crosslinkers for conjugation, immobilization, interaction studies, and structural probing. Compare linker chemistries suited to proteins, peptides, nucleic acids, and other biomolecules.

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Click Chemistry Reagents

718

Explore click chemistry reagents for fast bioconjugation, labeling, and modular synthesis workflows. Use this page to compare azide–alkyne and related tools for clean, efficient coupling.

Explore Click Chemistry Reagents →

Popular Products

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Showing 1-12 of 25,547

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  1. Esculin sesquihydrate
    Wish List Compare
    Esculin sesquihydrate
    CAS: 66778-17-4 PubChem CID: 16211025 Formula: C15H16O9 · 1.5H2O Molecular Weight: 367.31
    ≥98%
    In Stock Item #: E103661
    View Product
    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one;hydrate
    SMILES
    C1=CC(=O)OC2=CC(=C(C=C21)OC3C(C(C(C(O3)CO)O)O)O)O.O
    InChIKey
    CQYPGSKIFJFVDQ-QWFKVUSTSA-N
    InChI
    1S/C15H16O9.H2O/c16-5-10-12(19)13(20)14(21)15(24-10)23-9-3-6-1-2-11(18)22-8(6)4-7(9)17;/h1-4,10,12-17,19-21H,5H2;1H2/t10-,12-,13+,14-,15-;/m1./s1
    Synonyms
    7-Hydroxycoumarin-6-yl β-D-Glucopyranoside Sesquihydrate | 6-(beta-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-o...
  2. 2-Diethylaminoethyl hexanoate - ≥98% CAS No(10369-83-2) by Aladdin Scientific
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    2-Diethylaminoethyl hexanoate
    CAS: 10369-83-2 Formula: C12H25NO2 Molecular Weight: 215.33
    Liquid ≥98%
    In Stock Item #: M189447
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    2-(diethylamino)ethyl hexanoate
    SMILES
    CCCCCC(=O)OCCN(CC)CC
    InChIKey
    AEIJVYPRKAWFPN-UHFFFAOYSA-N
    InChI
    1S/C12H25NO2/c1-4-7-8-9-12(14)15-11-10-13(5-2)6-3/h4-11H2,1-3H3
    Synonyms
    DA-6 | Diethyl aminoethyl hexanoate
  3. (E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate
    Wish List Compare
    (E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate
    CAS: 1191901-33-3 Formula: C13H17NO5 Molecular Weight: 267.28
    ≥83%
    In Stock Item #: E486554
    View Product
    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    [(4E)-cyclooct-4-en-1-yl] (2,5-dioxopyrrolidin-1-yl) carbonate
    SMILES
    C1CC=CCCC(C1)OC(=O)ON2C(=O)CCC2=O
    InChIKey
    OUGQJOKGFAIFAQ-OWOJBTEDSA-N
    InChI
    1S/C13H17NO5/c15-11-8-9-12(16)14(11)19-13(17)18-10-6-4-2-1-3-5-7-10/h1-2,10H,3-9H2/b2-1+
    Synonyms
    (E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate | SCHEMBL1300090 | BP-22417 | 1191901-33-3 | TCO-NHS | Carboni...
  4. 3,4-Dimethoxybenzenesulfonyl fluoride - 95%, used for , CAS No. 95546-50-2, by Aladdin Scientific
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    3,4-Dimethoxybenzenesulfonyl fluoride
    CAS: 95546-50-2 Formula: C8H9FO4S Molecular Weight: 220.22
    ≥95%
    Out of Stock Item #: D467481
    View Product
    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    3,4-dimethoxybenzenesulfonyl fluoride
    SMILES
    COC1=C(C=C(C=C1)S(=O)(=O)F)OC
    InChIKey
    LCEVVNNKUAEPJM-UHFFFAOYSA-N
    InChI
    1S/C8H9FO4S/c1-12-7-4-3-6(14(9,10)11)5-8(7)13-2/h3-5H,1-2H3
    Synonyms
    F72595 | 3,4-Dimethoxybenzenesulfonyl fluoride, 95% | VS-0081 | 3,4-dimethoxybenzene-1-sulfonylfluoride | 3,4-dimetho...
  5. 1,2-Dibromoethane-1-sulfonyl fluoride - 90%, used for , CAS No. 103020-97-9, by Aladdin Scientific
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    1,2-Dibromoethane-1-sulfonyl fluoride
    CAS: 103020-97-9 Formula: C2H3Br2FO2S Molecular Weight: 269.92
    ≥90%
    Out of Stock Item #: D486510
    View Product
    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    1,2-dibromoethanesulfonyl fluoride
    SMILES
    C(C(S(=O)(=O)F)Br)Br
    InChIKey
    NIJDNCLEFCJVRL-UHFFFAOYSA-N
    InChI
    1S/C2H3Br2FO2S/c3-1-2(4)8(5,6)7/h2H,1H2
    Synonyms
    SuFEx-able plugin, DESF, SuFEx hub
  12. Tetrazine-PEG5-NHS ester - ≥95%, used for , CAS No. 1682653-80-0, by Aladdin Scientific
    Wish List Compare
    Tetrazine-PEG5-NHS ester
    CAS: 1682653-80-0 PubChem CID: 91757779 Formula: C27H36N6O10 Molecular Weight: 604.61
    ≥95%
    Out of Stock Item #: T463378
    View Product
    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-oxo-3-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methylamino]propoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
    SMILES
    C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCC(=O)NCC2=CC=C(C=C2)C3=NN=CN=N3
    InChIKey
    DUPHIQYIPUTDJS-UHFFFAOYSA-N
    InChI
    1S/C27H36N6O10/c34-23(28-19-21-1-3-22(4-2-21)27-31-29-20-30-32-27)7-9-38-11-13-40-15-17-42-18-16-41-14-12-39-10-8-26(37)43-33-24(35)5-6-25(33)36/h1-4,show more
    Synonyms
    Tz-PEG5-NHS
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Frequently Asked Questions

How do I choose a fluorescent probe for my experiment?
Match the probe to your imaging setup: excitation/emission wavelength, photostability, cell permeability, and target compatibility. Consider FRET pairs for protein interaction studies and quenched probes for activity-based imaging.
Which subcategory matches my chemical biology project?
PROTAC & Protein Degrader Building Blocks for targeted degradation, PEG Linkers for bioconjugation and pharmacokinetic improvement, Fluorescent Probes for imaging, Biotinylation Reagents for pull-down assays, and Crosslinkers for protein-protein interactions.
What specifications matter for chemical biology reagents?
Functional group reactivity, spacer length and PEG units, fluorophore brightness and stability, water solubility, cell membrane permeability, and storage requirements. Light sensitivity is critical for photoactivatable compounds.
Are bifunctional linkers and bioorthogonal handles available?
Yes. PEG Linkers includes homo- and hetero-bifunctional PEGs with various reactive groups (NHS, maleimide, azide, alkyne). Chemical Biology Tools covers click chemistry reagents for bioorthogonal labeling.
Chemical biology projects often require reagents that bridge synthesis and biological readout, and this category is organized with that in mind. It includes products used for labeling, conjugation, probe design, detection, target engagement studies, and controlled perturbation of biological systems. Relevant subgroups include fluorescent probes, biotinylation reagents, photoactivatable compounds, chromogenic and chemiluminescent substrates, aptamers, crosslinkers, PEG linkers, click chemistry reagents, and degrader-related building blocks. Researchers can compare products by reaction handle, signal modality, biological compatibility, spacer design, and downstream assay format to choose tools that fit both the chemistry and the biology of the experiment.
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  13. Antibody drug conjugate 1item
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Excitation (nm)
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Purity
  1. ≥97% 9175items
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  74. ≥99%(T) 1item
  75. ≥99%(TLC) 1item
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  77. ≥99.5%(HPLC) 1item
  78. ≥99.9985% metals basis 1item
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  18. for Cell culture 5items
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  43. Em:455nm 1item
  44. Em:470nm 1item
  45. Em:510nm 1item
  46. Em:511nm 1item
  47. Em:517nm 1item
  48. Em:526nm 1item
  49. Em:572nm 1item
  50. Em:575nm 1item
  51. Em:576nm 1item
  52. Em:578nm 1item
  53. Em:580nm 1item
  54. Em:613nm 1item
  55. Em:618nm 1item
  56. Em:660nm 1item
  57. Em:665nm 1item
  58. Em:695nm 1item
  59. Endotoxin Free 1item
  60. Ex:387nm 1item
  61. Ex:404nm 1item
  62. Ex:492nm 1item
  63. Ex:502nm 1item
  64. Ex:552nm 1item
  65. Ex:560nm 1item
  66. Ex:561nm 1item
  67. Ex:565nm 1item
  68. Ex:590nm 1item
  69. Ex:595nm 1item
  70. Ex:647nm 1item
  71. Ex:651nm 1item
  72. Ex:678nm 1item
  73. for TLC 1item
  74. histological grade 1item
  75. Purifed 1item
  76. Scintillation Pure 1item
  77. Sterile-filtered 1item
  78. Suitable for microbiology 1item
  79. UPS grade 1item
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  10. $4,500.00 - $25,014.91 118items
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