Proteinase-activated receptors

Proteinase-activated receptors (PARs) are a family of G protein-coupled receptors that are activated by proteolytic cleavage of their N-terminal domain by serine proteases . To date, four PARs have been identified in humans: PAR1, PAR2, PAR3, and PAR4. These receptors are widely expressed in various tissues and organs and play a role in regulating various biological processes such as inflammation, pain perception, and thrombosis.